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KMID : 0613820020120030325
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Journal of Life Science
2002 Volume.12 No. 3 p.325 ~ p.331
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Antioxidative activity of flavonoid rich extract of Oenothers odorate Jacquin on oxidation of low density lipoprotein
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Ryu Beung-Ho
Kim Hee-Sook
Cho Kyung-Jae
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Abstract
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There is growing interest in understanding the role and mechanisms of flavonoid as antioxidant on LDL. The antioxidative activity of flavonoid typically present in Oenothers odorate Jacquin was investigated in vitro using a human LDL oxidation assay. In present work, LDL was incubated with increasing concentrations of extracts of Oenothers odorate Jacquin and LDL oxidation was started by adding CuSO4 to the media. Substances in leaves extracts of Oenothers odorate Jacquin are capable of inhibiting the initiation and the propagation of LDL oxidation. They inhibit LDL oxidation, monitored by thiobarbituric acid-reactive substances(TBARS), as well as modification as shown through direct measurement of electrophoretic mobility, diene conjugates. Inhibition is a dose dependent effect that becomes already apparent at concentration of extracts as low as 40㎍/mL. Inhibition is almost complete at 80㎍/mL. Extracts of Oenothers odorate Jacquin were more potent antioxidative activity than either ascorbic acid and dl-α-tocopherol.
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KEYWORD
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Low density lipoprotein(LDL), antioxidative activity, Oenothers odorate Jacquin, flavonoid
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